Issue 22, 2016

A tryptophan-containing fluorescent intramolecular complex as a designer peptidic proton sensor

Abstract

Pyrene and tryptophan groups judiciously placed on a novel molecular scaffold, namely, bispidine exhibited fluorescence due to the formation of an unprecedented emissive intramolecular complex in polar solvents. Upon protonation, the emission signal from the pyrene unit enhances at the expense of the emission signal from the complex. The probe demonstrates good sensitivity, excellent selectivity, and adequate reversibility towards proton sensing. The present design based on the bispidine scaffold opens up newer opportunities for the design of novel bispidine-peptide sensors.

Graphical abstract: A tryptophan-containing fluorescent intramolecular complex as a designer peptidic proton sensor

Supplementary files

Article information

Article type
Paper
Submitted
22 Mar 2016
Accepted
04 May 2016
First published
04 May 2016

Phys. Chem. Chem. Phys., 2016,18, 15046-15053

A tryptophan-containing fluorescent intramolecular complex as a designer peptidic proton sensor

V. Haridas, A. Yadav, S. Sharma and S. Pandey, Phys. Chem. Chem. Phys., 2016, 18, 15046 DOI: 10.1039/C6CP01912A

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