Optimized Rhodamine B labeled mesoporous silica nanoparticles as fluorescent scaffolds for the immobilization of photosensitizers: a theranostic platform for optical imaging and photodynamic therapy

B. Martins Estevão; I. Miletto; L. Marchese; E. Gianotti

doi:10.1039/C6CP00906A

Optimized Rhodamine B labeled mesoporous silica nanoparticles as fluorescent scaffolds for the immobilization of photosensitizers: a theranostic platform for optical imaging and photodynamic therapy

B. Martins Estevão,^a^b I. Miletto,*^a L. Marchese^a and E. Gianotti^a

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* Corresponding authors

^a Department of Science and Technological Innovation and Nano-SiSTeMI Centre, Università del Piemonte Orientale, Viale T. Michel 11, 15121 Alessandria, Italy
E-mail: ivana.miletto@uniupo.it
Tel: +30 0131 360251

^b Nucleos Research of Photodynamic Therapy, Chemistry Department, State University of Maringá, Av. Colombo 5.790, Maringá, Brazil

Abstract

A highly efficient bifunctional mesoporous silica nanodevice coupling optical imaging with photodynamic therapy (PDT) was successfully prepared by using Rhodamine B as a contrast agent and verteporfin as a photosensitizer. The precise localization and high dispersion of the contrast agent in the nanoparticles is the key point to get higher fluorescence quantum yields with respect to the fluorophore in solution. To obtain this information photoluminescence spectroscopy coupled with fluorescence lifetime measurements was used, due to its high sensitivity. The bifunctional nanodevice showed good performances both in terms of quantum yield of the anchored Rhodamine B (Φ_RhB = 0.55) and the singlet oxygen delivery efficiency for PDT applications.

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Publication details

The article was received on 09 Feb 2016, accepted on 27 Feb 2016 and first published on 29 Feb 2016

Article type: Paper

DOI: 10.1039/C6CP00906A

Citation: Phys. Chem. Chem. Phys., 2016,18, 9042-9052

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Optimized Rhodamine B labeled mesoporous silica nanoparticles as fluorescent scaffolds for the immobilization of photosensitizers: a theranostic platform for optical imaging and photodynamic therapy

B. Martins Estevão, I. Miletto, L. Marchese and E. Gianotti, Phys. Chem. Chem. Phys., 2016, 18, 9042
DOI: 10.1039/C6CP00906A
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Physical Chemistry Chemical Physics

Optimized Rhodamine B labeled mesoporous silica nanoparticles as fluorescent scaffolds for the immobilization of photosensitizers: a theranostic platform for optical imaging and photodynamic therapy

Abstract

Supplementary files

Publication details

Optimized Rhodamine B labeled mesoporous silica nanoparticles as fluorescent scaffolds for the immobilization of photosensitizers: a theranostic platform for optical imaging and photodynamic therapy

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