Issue 85, 2016
From the journal:

Chemical Communications

Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition†

Matthew Huisman,a   Jessica K. White,b   Veronica G. Lewalski,a   Izabela Podgorski,cd   Claudia Turro*b  and  Jeremy J. Kodanko*ad  

* Corresponding authors

a Department of Chemistry, Wayne State University, Detroit, MI 48202, USA
E-mail: jkodanko@chem.wayne.edu
Tel: +1 313 577 9043

b Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
E-mail: turro1@osu.edu

c Department of Pharmacology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA

d Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, USA

Abstract

Photochemical control over irreversible inhibition was shown using Ru(II)-caged inhibitors of cathepsin L. Levels of control were dependent on where the Ru(II) complex was attached to the organic inhibitor, reaching >10 : 1 with optimal placement. A new strategy for photoreleasing Ru(II) fragments from inhibitor–enzyme conjugates is also reported.

Graphical abstract: Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition

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Article information

DOI
https://doi.org/10.1039/C6CC07083C
Article type
Communication
Submitted
29 Aug 2016
Accepted
22 Sep 2016
First published
06 Oct 2016

Chem. Commun., 2016,52, 12590-12593

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Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition

M. Huisman, J. K. White, V. G. Lewalski, I. Podgorski, C. Turro and J. J. Kodanko, Chem. Commun., 2016, 52, 12590 DOI: 10.1039/C6CC07083C

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