Issue 80, 2016

Ion beam induced 18F-radiofluorination: straightforward synthesis of gaseous radiotracers for the assessment of regional lung ventilation using positron emission tomography

Abstract

A simple, straightforward and efficient method for the synthesis of [18F]CF4 and [18F]SF6 based on an ion beam-induced isotopic exchange reaction is presented. Positron emission tomography ventilation studies in rodents using [18F]CF4 showed a uniform distribution of the radiofluorinated gas within the lungs and rapid elimination after discontinuation of the administration.

Graphical abstract: Ion beam induced 18F-radiofluorination: straightforward synthesis of gaseous radiotracers for the assessment of regional lung ventilation using positron emission tomography

Supplementary files

Article information

Article type
Communication
Submitted
28 Jul 2016
Accepted
07 Sep 2016
First published
07 Sep 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 11931-11934

Ion beam induced 18F-radiofluorination: straightforward synthesis of gaseous radiotracers for the assessment of regional lung ventilation using positron emission tomography

V. Gómez-Vallejo, A. Lekuona, Z. Baz, B. Szczupak, U. Cossío and J. Llop, Chem. Commun., 2016, 52, 11931 DOI: 10.1039/C6CC06249K

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