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Issue 69, 2016
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Controlled drug release to cancer cells from modular one-photon visible light-responsive micellar system

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Abstract

We present a one-photon visible light-responsive micellar system for efficient, on-demand delivery of small molecules. Release is mediated by a novel class of photochromic material – donor–acceptor Stenhouse adducts (DASAs). We demonstrate controlled delivery of small molecules such as the chemotherapeutic agent (paclitaxel) to human breast cancer cells triggered by micellar switching with low intensity, visible light.

Graphical abstract: Controlled drug release to cancer cells from modular one-photon visible light-responsive micellar system

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Publication details

The article was received on 16 May 2016, accepted on 01 Aug 2016 and first published on 01 Aug 2016


Article type: Communication
DOI: 10.1039/C6CC04127B
Citation: Chem. Commun., 2016,52, 10525-10528
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    Controlled drug release to cancer cells from modular one-photon visible light-responsive micellar system

    S. O. Poelma, S. S. Oh, S. Helmy, A. S. Knight, G. L. Burnett, H. T. Soh, C. J. Hawker and J. Read de Alaniz, Chem. Commun., 2016, 52, 10525
    DOI: 10.1039/C6CC04127B

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