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Issue 50, 2016
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Highly stereoselective cyclopropanation of diazo Weinreb amides catalyzed by chiral Ru(II)–Amm–Pheox complexes

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Abstract

The first highly stereoselective cyclopropanation of diazo Weinreb amides with olefins was accomplished using chiral Ru(II)–Amm–Pheox complex 7a to give the corresponding chiral cyclopropyl Weinreb amides in high yields (up to 99%) with excellent diastereoselectivities (up to 99 : 1 dr) and enantioselectivities (up to 96% ee).

Graphical abstract: Highly stereoselective cyclopropanation of diazo Weinreb amides catalyzed by chiral Ru(ii)–Amm–Pheox complexes

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Publication details

The article was received on 23 Mar 2016, accepted on 20 May 2016 and first published on 20 May 2016


Article type: Communication
DOI: 10.1039/C6CC02498J
Citation: Chem. Commun., 2016,52, 7814-7817
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    Highly stereoselective cyclopropanation of diazo Weinreb amides catalyzed by chiral Ru(II)–Amm–Pheox complexes

    S. Chanthamath, H. S. A. Mandour, T. M. T. Tong, K. Shibatomi and S. Iwasa, Chem. Commun., 2016, 52, 7814
    DOI: 10.1039/C6CC02498J

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