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Issue 27, 2016
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[11C]Ascorbic and [11C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography

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Abstract

Here we report the radiosynthesis of an endogenous redox pair, [11C]ascorbic acid ([11C]VitC) and [11C]dehydroascorbic acid ([11C]DHA), the reduced and oxidized forms of vitamin C, and their application to ROS sensing. These results provide the basis for in vivo detection of ROS using positron emission tomography (PET).

Graphical abstract: [11C]Ascorbic and [11C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography

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Publication details

The article was received on 28 Jan 2016, accepted on 01 Mar 2016 and first published on 01 Mar 2016


Article type: Communication
DOI: 10.1039/C6CC00895J
Citation: Chem. Commun., 2016,52, 4888-4890
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    [11C]Ascorbic and [11C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography

    V. N. Carroll, C. Truillet, B. Shen, R. R. Flavell, X. Shao, M. J. Evans, H. F. VanBrocklin, P. J. H. Scott, F. T. Chin and D. M. Wilson, Chem. Commun., 2016, 52, 4888
    DOI: 10.1039/C6CC00895J

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