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Issue 58, 2016
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Passive tumour targeting and extravasation of cylindrical polymer brushes in mouse xenografts

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Abstract

The shape-persistent nature and conformation of cylindrical polymer brushes (CPBs) present opportunities to explore the properties of anisotropic (i.e. non spherical) nanomaterials in biological settings. This study shows that CPBs with lengths of up to 1 μm are able to passively target tumours via the enhanced permeation and retention (EPR) effect. Moreover, large CPBs with higher aspect ratios (ARs) were able to penetrate tumours with similar efficiencies to much smaller systems with lower ARs.

Graphical abstract: Passive tumour targeting and extravasation of cylindrical polymer brushes in mouse xenografts

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Publication details

The article was received on 16 Jan 2016, accepted on 17 Mar 2016 and first published on 29 Mar 2016


Article type: Communication
DOI: 10.1039/C6CC00447D
Citation: Chem. Commun., 2016,52, 9121-9124
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    Passive tumour targeting and extravasation of cylindrical polymer brushes in mouse xenografts

    M. Müllner, D. Mehta, C. J. Nowell and C. J. H. Porter, Chem. Commun., 2016, 52, 9121
    DOI: 10.1039/C6CC00447D

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