Issue 25, 2016
From the journal:

Chemical Communications

A fluorescent surrogate of thymidine in duplex DNA†

Guillaume Mata,a   Olivia P. Schmidta  and  Nathan W. Luedtke*a  

* Corresponding authors

a Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
E-mail: nathan.luedtke@chem.uzh.ch

Abstract

DMAT is a new fluorescent thymidine mimic composed of 2′-deoxyuridine fused to dimethylaniline. DMAT exhibits the same pKa and base pairing characteristics as native thymidine residues, and its fluorescence properties are highly sensitive to nucleobase ionization, base pairing and metal binding.

Graphical abstract: A fluorescent surrogate of thymidine in duplex DNA

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Article information

DOI
https://doi.org/10.1039/C5CC09552B
Article type
Communication
Submitted
18 Nov 2015
Accepted
25 Feb 2016
First published
25 Feb 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 4718-4721

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A fluorescent surrogate of thymidine in duplex DNA

G. Mata, O. P. Schmidt and N. W. Luedtke, Chem. Commun., 2016, 52, 4718 DOI: 10.1039/C5CC09552B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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