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Issue 25, 2016
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A fluorescent surrogate of thymidine in duplex DNA

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Abstract

DMAT is a new fluorescent thymidine mimic composed of 2′-deoxyuridine fused to dimethylaniline. DMAT exhibits the same pKa and base pairing characteristics as native thymidine residues, and its fluorescence properties are highly sensitive to nucleobase ionization, base pairing and metal binding.

Graphical abstract: A fluorescent surrogate of thymidine in duplex DNA

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Publication details

The article was received on 18 Nov 2015, accepted on 25 Feb 2016 and first published on 25 Feb 2016


Article type: Communication
DOI: 10.1039/C5CC09552B
Citation: Chem. Commun., 2016,52, 4718-4721
  • Open access: Creative Commons BY license
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    A fluorescent surrogate of thymidine in duplex DNA

    G. Mata, O. P. Schmidt and N. W. Luedtke, Chem. Commun., 2016, 52, 4718
    DOI: 10.1039/C5CC09552B

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