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Issue 1, 2017
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Synthesis of ramariolide natural products and discovery of their targets in mycobacteria

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Abstract

Ramariolides A–D are natural products with antibacterial activity. To exploit their cellular mechanism, we here devise the first total synthesis and prepare a photoprobe for target identification. Antibacterial testing against several pathogenic strains including Mycobacterium tuberculosis revealed the highest potency for ramariolide A. Chemical proteomics unraveled binding to essential proteins for amino acid anabolism.

Graphical abstract: Synthesis of ramariolide natural products and discovery of their targets in mycobacteria

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Publication details

The article was received on 17 Oct 2016, accepted on 11 Nov 2016 and first published on 11 Nov 2016


Article type: Communication
DOI: 10.1039/C6CC08365J
Citation: Chem. Commun., 2017,53, 107-110
  • Open access: Creative Commons BY-NC license
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    Synthesis of ramariolide natural products and discovery of their targets in mycobacteria

    J. Lehmann, J. Richers, A. Pöthig and S. A. Sieber, Chem. Commun., 2017, 53, 107
    DOI: 10.1039/C6CC08365J

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