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Issue 96, 2016
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A CoII complex for 19F MRI-based detection of reactive oxygen species

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Abstract

A fluorinated, air-stable cobalt(II) complex serves as a turn-on 19F magnetic resonance imaging (MRI) tracer for reactive oxygen species including H2O2. Upon oxidation with H2O2, the complex converts from paramagnetic high spin CoII to diamagnetic low spin CoIII resulting in a chemical shift change and enhancement in 19F NMR signal. Further, the oxidation can be reversed in the presence of reductant Na2S2O4. The turn-on response is demonstrated by 19F MRI, characterized by a ∼2–3 fold enhancement in signal.

Graphical abstract: A CoII complex for 19F MRI-based detection of reactive oxygen species

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Publication details

The article was received on 11 Oct 2016, accepted on 08 Nov 2016 and first published on 08 Nov 2016


Article type: Communication
DOI: 10.1039/C6CC08207F
Citation: Chem. Commun., 2016,52, 13885-13888
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    A CoII complex for 19F MRI-based detection of reactive oxygen species

    M. Yu, D. Xie, K. P. Phan, J. S. Enriquez, J. J. Luci and E. L. Que, Chem. Commun., 2016, 52, 13885
    DOI: 10.1039/C6CC08207F

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