Issue 85, 2016
From the journal:

Chemical Communications

Structural regulation by a G-quadruplex ligand increases binding abilities of G-quadruplex-forming aptamers†

Kaori Tsukakoshi,a   Yuri Ikuta,a   Koichi Abe,a   Wataru Yoshida,b   Keisuke Iida,c   Yue Ma,a   Kazuo Nagasawa,a   Koji Sodea  and  Kazunori Ikebukuro*a  

* Corresponding authors

a Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan
E-mail: ikebu@cc.tuat.ac.jp
Tel: +81-(0)42-388-7030

b School of Biotechnology and Bioscience, Tokyo University of Technology, 1404-1 Katakura-cho, Hachioji, Tokyo 192-0982, Japan

c Graduate School of Science and Engineering, Saitama University, Shimo-okubo 255, Sakura-ku, Saitama 338-8570, Japan

Abstract

We report that a G-quadruplex-specific compound induced structural changes in G-quadruplex-forming DNA aptamers and stabilized the folded structures, making them suitable for targeted proteins and enhancing their binding properties.

Graphical abstract: Structural regulation by a G-quadruplex ligand increases binding abilities of G-quadruplex-forming aptamers

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Article information

DOI
https://doi.org/10.1039/C6CC07552E
Article type
Communication
Submitted
16 Sep 2016
Accepted
29 Sep 2016
First published
30 Sep 2016

Chem. Commun., 2016,52, 12646-12649

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Structural regulation by a G-quadruplex ligand increases binding abilities of G-quadruplex-forming aptamers

K. Tsukakoshi, Y. Ikuta, K. Abe, W. Yoshida, K. Iida, Y. Ma, K. Nagasawa, K. Sode and K. Ikebukuro, Chem. Commun., 2016, 52, 12646 DOI: 10.1039/C6CC07552E

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