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Issue 100, 2016
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Lysine linkage in abasic site-binding ligand–thiazole orange conjugates for improved binding affinity to orphan nucleobases in DNA/RNA hybrids

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Abstract

Introduction of lysine linkage in the conjugate between abasic site-binding ligands and thiazole orange significantly improved the binding affinity for target orphan adenine or uracil nucleobase in DNA/RNA hybrids.

Graphical abstract: Lysine linkage in abasic site-binding ligand–thiazole orange conjugates for improved binding affinity to orphan nucleobases in DNA/RNA hybrids

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Publication details

The article was received on 05 Sep 2016, accepted on 17 Nov 2016 and first published on 17 Nov 2016


Article type: Communication
DOI: 10.1039/C6CC07236D
Citation: Chem. Commun., 2016,52, 14446-14449
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    Lysine linkage in abasic site-binding ligand–thiazole orange conjugates for improved binding affinity to orphan nucleobases in DNA/RNA hybrids

    Y. Sato, H. Saito, D. Aoki, N. Teramae and S. Nishizawa, Chem. Commun., 2016, 52, 14446
    DOI: 10.1039/C6CC07236D

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