Issue 84, 2016
From the journal:

Chemical Communications

Enantioselective formation of cyclopropane spiroindenes from benzofulvenes by phase transfer catalysis†

Bjarke S. Donslund,a   Nicolaj Inunnguaq Jessen,a   Joakim Bøgelund Jakobsen,a   Alicia Monleón,a   Rune Pagh Nielsena  and  Karl Anker Jørgensen*a  

* Corresponding authors

a Department of Chemistry, Aarhus University, DK-8000 Aarhus C, Denmark
E-mail: kaj@chem.au.dk

Abstract

The enantio- and diastereoselective formation of indenes spirofused to highly substituted cyclopropanes is described. The application of a new cinchona alkaloid derived ammonium salt in a phase transfer catalysis setup facilitates high selectivity and excellent yields at low catalyst loadings (0.1–1.0 mol%).

Graphical abstract: Enantioselective formation of cyclopropane spiroindenes from benzofulvenes by phase transfer catalysis

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Article information

DOI
https://doi.org/10.1039/C6CC07170H
Article type
Communication
Submitted
01 Sep 2016
Accepted
27 Sep 2016
First published
27 Sep 2016

Chem. Commun., 2016,52, 12474-12477

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Enantioselective formation of cyclopropane spiroindenes from benzofulvenes by phase transfer catalysis

B. S. Donslund, N. I. Jessen, J. B. Jakobsen, A. Monleón, R. P. Nielsen and K. A. Jørgensen, Chem. Commun., 2016, 52, 12474 DOI: 10.1039/C6CC07170H

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