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Issue 81, 2016
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Palladium-catalyzed Sonogashira coupling of amides: access to ynones via C–N bond cleavage

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Abstract

The first palladium-catalyzed Sonogashira coupling of amides has been developed, which proceeds via a selective cleavage of the N-acylsaccharin C–N bond. Notably, the new approach employs N-acylsaccharins as coupling partners to give ynones in good to excellent yield. This protocol can be efficiently utilized in the synthesis of a broad array of ynones under low catalyst loading and Cu-free conditions.

Graphical abstract: Palladium-catalyzed Sonogashira coupling of amides: access to ynones via C–N bond cleavage

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Publication details

The article was received on 04 Aug 2016, accepted on 06 Sep 2016 and first published on 09 Sep 2016


Article type: Communication
DOI: 10.1039/C6CC06428K
Citation: Chem. Commun., 2016,52, 12076-12079
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    Palladium-catalyzed Sonogashira coupling of amides: access to ynones via C–N bond cleavage

    M. Cui, H. Wu, J. Jian, H. Wang, C. Liu, S. Daniel and Z. Zeng, Chem. Commun., 2016, 52, 12076
    DOI: 10.1039/C6CC06428K

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