Jump to main content
Jump to site search

Issue 92, 2016
Previous Article Next Article

Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA

Author affiliations

Abstract

Here we present a chemical-biology study in the model soil bacterium Paracoccus denitrificans, where we show ligand-specific control of nitrate assimilation. Stabilization of a G-quadruplex in the promoter region of the nas genes, encoding the assimilatory nitrate/nitrite reductase system, is achieved using known quadruplex ligands and results in attenuation of gene transcription.

Graphical abstract: Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Jul 2016, accepted on 20 Oct 2016 and first published on 01 Nov 2016


Article type: Communication
DOI: 10.1039/C6CC06057A
Citation: Chem. Commun., 2016,52, 13511-13514
  • Open access: Creative Commons BY license
  •   Request permissions

    Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA

    Z. A. E. Waller, B. J. Pinchbeck, B. S. Buguth, T. G. Meadows, D. J. Richardson and A. J. Gates, Chem. Commun., 2016, 52, 13511
    DOI: 10.1039/C6CC06057A

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements