An efficient two-photon fluorescent probe for monitoring mitochondrial singlet oxygen in tissues during photodynamic therapy

Hong-Wen Liu; Shuai Xu; Peng Wang; Xiao-Xiao Hu; Jing Zhang; Lin Yuan; Xiao-Bing Zhang; Weihong Tan

doi:10.1039/C6CC05880A

An efficient two-photon fluorescent probe for monitoring mitochondrial singlet oxygen in tissues during photodynamic therapy

Hong-Wen Liu,^a Shuai Xu,^a Peng Wang,^a Xiao-Xiao Hu,^a Jing Zhang,^a Lin Yuan,^a Xiao-Bing Zhang*^a and Weihong Tan^a

Author affiliations

* Corresponding authors

^a Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
E-mail: xbzhang@hnu.edu.cn

Abstract

A promising two-photon fluorescent probe MNAH for detecting ¹O₂ during the PDT process in mitochondria was proposed for the first time. MNAH was successfully applied for two-photon imaging of ¹O₂ in living cells and tissues during the PDT process with deep-tissue imaging depth. MNAH can be a powerful molecular tool for studying ¹O₂ generation in mitochondria during the PDT process.

Supplementary files

Publication details

The article was received on 17 Jul 2016, accepted on 16 Sep 2016 and first published on 21 Sep 2016

Article type: Communication

DOI: 10.1039/C6CC05880A

Citation: Chem. Commun., 2016,52, 12330-12333

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An efficient two-photon fluorescent probe for monitoring mitochondrial singlet oxygen in tissues during photodynamic therapy

H. Liu, S. Xu, P. Wang, X. Hu, J. Zhang, L. Yuan, X. Zhang and W. Tan, Chem. Commun., 2016, 52, 12330
DOI: 10.1039/C6CC05880A
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Chemical Communications

An efficient two-photon fluorescent probe for monitoring mitochondrial singlet oxygen in tissues during photodynamic therapy

Abstract

Supplementary files

Publication details

An efficient two-photon fluorescent probe for monitoring mitochondrial singlet oxygen in tissues during photodynamic therapy

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