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Issue 73, 2016
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Membrane-disrupting iridium(III) oligocationic organometallopeptides

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Abstract

A series of oligoarginine peptide derivatives containing cyclometallated iridium(III) units display remarkable cytotoxicity, comparable to that of cisplatin. In vitro studies with unilamellar vesicles support a membrane-disrupting mechanism of action.

Graphical abstract: Membrane-disrupting iridium(iii) oligocationic organometallopeptides

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Publication details

The article was received on 04 Jul 2016, accepted on 12 Aug 2016 and first published on 19 Aug 2016


Article type: Communication
DOI: 10.1039/C6CC05537K
Citation: Chem. Commun., 2016,52, 11008-11011
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    Membrane-disrupting iridium(III) oligocationic organometallopeptides

    I. Salvadó, I. Gamba, J. Montenegro, J. Martínez-Costas, J. M. Brea, M. I. Loza, M. Vázquez López and M. E. Vázquez, Chem. Commun., 2016, 52, 11008
    DOI: 10.1039/C6CC05537K

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