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Issue 57, 2016
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Direct amidation of unprotected amino acids using B(OCH2CF3)3

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Abstract

A commercially available borate ester, B(OCH2CF3)3, can be used to achieve protecting-group free direct amidation of α-amino acids with a range of amines in cyclopentyl methyl ether. The method can be applied to the synthesis of medicinally relevant compounds, and can be scaled up to obtain gram quantities of products.

Graphical abstract: Direct amidation of unprotected amino acids using B(OCH2CF3)3

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Publication details

The article was received on 29 Jan 2016, accepted on 22 Jun 2016 and first published on 22 Jun 2016


Article type: Communication
DOI: 10.1039/C6CC05147B
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Citation: Chem. Commun., 2016,52, 8846-8849
  • Open access: Creative Commons BY license
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    Direct amidation of unprotected amino acids using B(OCH2CF3)3

    R. M. Lanigan, V. Karaluka, M. T. Sabatini, P. Starkov, M. Badland, L. Boulton and T. D. Sheppard, Chem. Commun., 2016, 52, 8846
    DOI: 10.1039/C6CC05147B

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