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Issue 59, 2016
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A proline-derived transannular N-cap for nucleation of short α-helical peptides

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Abstract

We report herein a proline-derived transannular N-cap as a helix nucleating template in diverse bio-related peptide sequences via macrolactamization on resin. This approach takes advantage of synergistic stabilization effects of both N-capping properties of proline and substitution of a main chain hydrogen bond with a covalent bond.

Graphical abstract: A proline-derived transannular N-cap for nucleation of short α-helical peptides

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Publication details

The article was received on 03 Jun 2016, accepted on 22 Jun 2016 and first published on 22 Jun 2016


Article type: Communication
DOI: 10.1039/C6CC04672J
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2016,52, 9275-9278
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    A proline-derived transannular N-cap for nucleation of short α-helical peptides

    Y. Tian, D. Wang, J. Li, C. Shi, H. Zhao, X. Niu and Z. Li, Chem. Commun., 2016, 52, 9275
    DOI: 10.1039/C6CC04672J

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