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Issue 63, 2016
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A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds

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Abstract

A synthetic approach to diverse scaffolds was developed that was inspired by diterpene biosynthesis. Initial scaffolds, generated using Diels–Alder reactions of furyl-functionalised amines, were transformed into alternative scaffolds using cleavage, ring expansion, annulation and rearrangement reactions. In total, 25 diverse scaffolds were prepared that were shown to have high natural product-likeness.

Graphical abstract: A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds

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Publication details

The article was received on 03 Jun 2016, accepted on 13 Jul 2016 and first published on 18 Jul 2016


Article type: Communication
DOI: 10.1039/C6CC04662B
Citation: Chem. Commun., 2016,52, 9837-9840
  • Open access: Creative Commons BY-NC license
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    A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds

    J. D. Firth, P. G. E. Craven, M. Lilburn, A. Pahl, S. P. Marsden and A. Nelson, Chem. Commun., 2016, 52, 9837
    DOI: 10.1039/C6CC04662B

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