Issue 70, 2016
From the journal:

Chemical Communications

Hollow silica nanospheres coated with insoluble calcium salts for pH-responsive sustained release of anticancer drugs†

Yuming Guo,*ab   Qilong Fang,a   Han Li,a   Weike Shi,a   Jie Zhang,a   Jing Feng,a   Weili Jiaa  and  Lin Yang*ab  

* Corresponding authors

a Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan 453007, P. R. China
E-mail: guoyuming@htu.edu.cn, yanglin1819@163.com

b Henan Key Laboratory of Green Chemical Media and Reactions, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, P. R. China

Abstract

Hollow silica nanospheres coated with biocompatible and pH-sensitive inorganic insoluble calcium salts including calcium carbonate and hydroxyapatite have been successfully prepared. The results indicate that the nanospheres can efficiently load doxorubicin and release it in a pH-responsive and sustained manner, and improve the treatment efficacy significantly.

Graphical abstract: Hollow silica nanospheres coated with insoluble calcium salts for pH-responsive sustained release of anticancer drugs

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Article information

DOI
https://doi.org/10.1039/C6CC04538C
Article type
Communication
Submitted
31 May 2016
Accepted
01 Aug 2016
First published
01 Aug 2016

Chem. Commun., 2016,52, 10652-10655

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Hollow silica nanospheres coated with insoluble calcium salts for pH-responsive sustained release of anticancer drugs

Y. Guo, Q. Fang, H. Li, W. Shi, J. Zhang, J. Feng, W. Jia and L. Yang, Chem. Commun., 2016, 52, 10652 DOI: 10.1039/C6CC04538C

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