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Issue 83, 2016
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Azobenzene photocontrol of peptides and proteins

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Abstract

The last few years have witnessed significant advances in the use of light as a stimulus to control biomolecular interactions. Great efforts have been devoted to the development of genetically encoded optobiological and small photochromic switches. Newly discovered small molecules now allow researchers to build molecular systems that are sensitive to a wider range of wavelengths of light than ever before with improved switching fidelities and increased lifetimes of the photoactivated states. Because these molecules are relatively small and adopt predictable conformations they are well suited as tools to interrogate cellular function in a spatially and temporally contolled fashion and for applications in photopharmacology.

Graphical abstract: Azobenzene photocontrol of peptides and proteins

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Publication details

The article was received on 12 May 2016, accepted on 01 Aug 2016 and first published on 19 Aug 2016


Article type: Feature Article
DOI: 10.1039/C6CC04004G
Citation: Chem. Commun., 2016,52, 12262-12277
  • Open access: Creative Commons BY license
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    Azobenzene photocontrol of peptides and proteins

    R. J. Mart and R. K. Allemann, Chem. Commun., 2016, 52, 12262
    DOI: 10.1039/C6CC04004G

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