Issue 55, 2016
From the journal:

Chemical Communications

Incorporation and visualization of azido-functionalized N-oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells†

T. Walter, ORCID logo ‡a   L. Collenburg,‡b   L. Japtok,c   B. Kleuser,c   S. Schneider-Schaulies,b   N. Müller,b   J. Becam,d   A. Schubert-Unkmeir,d   J. N. Kong,e   E. Bieberiche  and  J. Seibel*a  

* Corresponding authors

a Institute for Organic Chemistry, Julius-Maximilians University Würzburg, Am Hubland C1, Würzburg, Germany
E-mail: seibel@chemie.uni-wuerzburg.de

b Institute of Virology and Immunobiology, Versbacher Str. 7, Würzburg, Germany

c Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert Allee 114-116, Nuthetal, Potsdam, Germany

d Institute of Hygiene and Microbiology, Josef-Schneider-Straße 2/E1, Würzburg, Germany

e Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, USA

Abstract

The synthesis and biological evaluation of azido-N-oleoyl serinol is reported. It mimicks biofunctional lipid ceramides and has shown to be capable of click reactions for cell membrane imaging in Jurkat and human brain microvascular endothelial cells.

Graphical abstract: Incorporation and visualization of azido-functionalized N-oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells

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Article information

DOI
https://doi.org/10.1039/C6CC02879A
Article type
Communication
Submitted
06 Apr 2016
Accepted
14 Jun 2016
First published
16 Jun 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 8612-8614

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Incorporation and visualization of azido-functionalized N-oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells

T. Walter, L. Collenburg, L. Japtok, B. Kleuser, S. Schneider-Schaulies, N. Müller, J. Becam, A. Schubert-Unkmeir, J. N. Kong, E. Bieberich and J. Seibel, Chem. Commun., 2016, 52, 8612 DOI: 10.1039/C6CC02879A

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