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Issue 29, 2016
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Discovery of a 19F MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells

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Abstract

Salinomycin is a promising anti-cancer agent which selectively targets cancer stem cells. To improve its potency and selectivity, an analog library of salinomycin was generated by site-specific modification and CuAAc derivatization. Through a cytotoxicity analysis of the library, a fluorinated analog with high potency, selectivity, and 19F MRI sensitivity was discovered as a novel theranostic agent.

Graphical abstract: Discovery of a 19F MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells

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Publication details

The article was received on 19 Feb 2016, accepted on 10 Mar 2016 and first published on 10 Mar 2016


Article type: Communication
DOI: 10.1039/C6CC01508E
Citation: Chem. Commun., 2016,52, 5136-5139
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    Discovery of a 19F MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells

    Q. Shi, Y. Li, S. Bo, X. Li, P. Zhao, Q. Liu, Z. Yang, H. Cong, H. Deng, M. Chen, S. Chen, X. Zhou, H. Ding and Z. Jiang, Chem. Commun., 2016, 52, 5136
    DOI: 10.1039/C6CC01508E

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