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Issue 31, 2016
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Small molecule-mediated duplex formation of nucleic acids with ‘incompatible’ backbones

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Abstract

Proflavine, a known intercalator of DNA and RNA, promotes duplex formation by nucleic acids with natural and non-natural backbones that otherwise form duplexes with low thermal stability, and even some that show no sign of duplex formation in the absence of proflavine. These findings demonstrate the potential for intercalators to be used as cofactors for the assembly of rationally designed nucleic acid structures, and could provide fundamental insights regarding intercalation of natural nucleic acid duplexes.

Graphical abstract: Small molecule-mediated duplex formation of nucleic acids with ‘incompatible’ backbones

  • This article is part of the themed collection: Foldamers
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Publication details

The article was received on 26 Jan 2016, accepted on 09 Mar 2016 and first published on 09 Mar 2016


Article type: Communication
DOI: 10.1039/C6CC00779A
Citation: Chem. Commun., 2016,52, 5436-5439
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    Small molecule-mediated duplex formation of nucleic acids with ‘incompatible’ backbones

    B. J. Cafferty, C. Musetti, K. Kim, E. D. Horowitz, R. Krishnamurthy and N. V. Hud, Chem. Commun., 2016, 52, 5436
    DOI: 10.1039/C6CC00779A

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