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Issue 40, 2016
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Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo

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Abstract

Bacterial metallo-β-lactamases (MBLs) are involved in resistance to β-lactam antibiotics including cephalosporins. Human SNM1A and SNM1B are MBL superfamily exonucleases that play a key role in the repair of DNA interstrand cross-links, which are induced by antitumour chemotherapeutics, and are therefore targets for cancer chemosensitization. We report that cephalosporins are competitive inhibitors of SNM1A and SNM1B exonuclease activity; both the intact β-lactam and their hydrolysed products are active. This discovery provides a lead for the development of potent and selective SNM1A and SNM1B inhibitors.

Graphical abstract: Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo

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Publication details

The article was received on 19 Jan 2016, accepted on 18 Apr 2016 and first published on 18 Apr 2016


Article type: Communication
DOI: 10.1039/C6CC00529B
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Citation: Chem. Commun., 2016,52, 6727-6730
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    Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo

    S. Y. Lee, J. Brem, I. Pettinati, T. D. W. Claridge, O. Gileadi, C. J. Schofield and P. J. McHugh, Chem. Commun., 2016, 52, 6727
    DOI: 10.1039/C6CC00529B

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