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Issue 24, 2016
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Photoactivatable CO release from engineered protein crystals to modulate NF-κB activation

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Abstract

Photoactivatable CO releasing protein crystals were developed by immobilization of Mn carbonyl complexes in polyhedral crystals, which are spontaneously formed in insect cells. The photoactivatable CO release from the engineered protein crystals activates nuclear factor kappa B (NF-κB) upon stimulation by visible light irradiation with suppression of cytotoxicity of the Mn complex.

Graphical abstract: Photoactivatable CO release from engineered protein crystals to modulate NF-κB activation

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Publication details

The article was received on 20 Dec 2015, accepted on 29 Feb 2016 and first published on 01 Mar 2016


Article type: Communication
DOI: 10.1039/C5CC10440H
Citation: Chem. Commun., 2016,52, 4545-4548
  • Open access: Creative Commons BY-NC license
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    Photoactivatable CO release from engineered protein crystals to modulate NF-κB activation

    H. Tabe, T. Shimoi, M. Boudes, S. Abe, F. Coulibaly, S. Kitagawa, H. Mori and T. Ueno, Chem. Commun., 2016, 52, 4545
    DOI: 10.1039/C5CC10440H

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