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Issue 19, 2016
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7-(Benzofuran-2-yl)-7-deazadeoxyguanosine as a fluorescence turn-ON probe for single-strand DNA binding protein

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Abstract

7-(Benzofuran-2-yl)-7-deazadeoxyguanosine (BFdG) was synthesized and incorporated into an oligodeoxynucleotide (ODN). The single-stranded ODN containing BFdG shows 91-fold fluorescence enhancement upon binding of single-strand DNA binding protein.

Graphical abstract: 7-(Benzofuran-2-yl)-7-deazadeoxyguanosine as a fluorescence turn-ON probe for single-strand DNA binding protein

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Publication details

The article was received on 24 Nov 2015, accepted on 01 Feb 2016 and first published on 01 Feb 2016


Article type: Communication
DOI: 10.1039/C5CC09700B
Citation: Chem. Commun., 2016,52, 3809-3812
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    7-(Benzofuran-2-yl)-7-deazadeoxyguanosine as a fluorescence turn-ON probe for single-strand DNA binding protein

    M. Tokugawa, Y. Masaki, J. C. Canggadibrata, K. Kaneko, T. Shiozawa, T. Kanamori, M. Grøtli, L. M. Wilhelmsson, M. Sekine and K. Seio, Chem. Commun., 2016, 52, 3809
    DOI: 10.1039/C5CC09700B

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