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Issue 11, 2016
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Synthesis of inherently chiral calixarenes via direct mercuration of the partial cone conformation

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Abstract

Direct mercuration of calix[4]arene immobilized in the partial cone conformation led to the meta-substituted isomer which was subsequently subjected to Pd-catalysed coupling (C–H activation) with the neighbouring aromatic subunit. Regioselective mercuration thus enabled access to a novel type of inherently chiral calixarenes with a highly distorted cavity potentially applicable to the design of new chiral receptors.

Graphical abstract: Synthesis of inherently chiral calixarenes via direct mercuration of the partial cone conformation

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Publication details

The article was received on 12 Nov 2015, accepted on 21 Dec 2015 and first published on 21 Dec 2015


Article type: Communication
DOI: 10.1039/C5CC09388K
Citation: Chem. Commun., 2016,52, 2366-2369
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    Synthesis of inherently chiral calixarenes via direct mercuration of the partial cone conformation

    P. Slavík, M. Kohout, S. Böhm, V. Eigner and P. Lhoták, Chem. Commun., 2016, 52, 2366
    DOI: 10.1039/C5CC09388K

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