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Issue 5, 2016
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Improved oxidation of aromatic and aliphatic hydrocarbons using rate enhancing variants of P450Bm3 in combination with decoy molecules

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Abstract

Enzyme performance can be improved using decoy molecules or engineered variants to accelerate the activity without affecting selectivity. Here we combine a rate accelerator variant of cytochrome P450Bm3 with decoy molecules to enhance the oxidation activity of a range of small organic molecules. This combined approach offers superior biocatalytic efficiency without modifying the product distribution.

Graphical abstract: Improved oxidation of aromatic and aliphatic hydrocarbons using rate enhancing variants of P450Bm3 in combination with decoy molecules

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Publication details

The article was received on 07 Nov 2015, accepted on 17 Nov 2015 and first published on 17 Nov 2015


Article type: Communication
DOI: 10.1039/C5CC09247G
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2016,52, 1036-1039
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    Improved oxidation of aromatic and aliphatic hydrocarbons using rate enhancing variants of P450Bm3 in combination with decoy molecules

    S. D. Munday, O. Shoji, Y. Watanabe, L. Wong and S. G. Bell, Chem. Commun., 2016, 52, 1036
    DOI: 10.1039/C5CC09247G

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