Jump to main content
Jump to site search

Issue 5, 2016
Previous Article Next Article

Click and release: fluoride cleavable linker for mild bioorthogonal separation

Author affiliations

Abstract

Herein, we present a water dispersable, magnetic nanoparticle supported “click and release” system. The cleavable linker has been synthesized by using a strain-promoted copper-free “click” reagent to establish the specific link and a fluoride cleavable silane moiety for mild cleavage. Small organic molecules, azide-bearing dyes and functionalized enzymes have been bound to the magnetic particle and released in a bioorthogonal way.

Graphical abstract: Click and release: fluoride cleavable linker for mild bioorthogonal separation

Back to tab navigation

Supplementary files

Publication details

The article was received on 14 Sep 2015, accepted on 16 Nov 2015 and first published on 16 Nov 2015


Article type: Communication
DOI: 10.1039/C5CC07692G
Author version
available:
Download author version (PDF)
Citation: Chem. Commun., 2016,52, 938-941
  •   Request permissions

    Click and release: fluoride cleavable linker for mild bioorthogonal separation

    E. M. Schneider, M. Zeltner, V. Zlateski, R. N. Grass and W. J. Stark, Chem. Commun., 2016, 52, 938
    DOI: 10.1039/C5CC07692G

Search articles by author

Spotlight

Advertisements