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Issue 12, 2016
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Glucose-bearing biodegradable poly(amino acid) and poly(amino acid)-poly(ester) conjugates for controlled payload release

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Abstract

The glucoseamine-initiated ring-opening polymerisation of amino acid N-carboxyanhydrides and O-carboxanhydrides to yield amphiphilic block copolymers that are capable of self-assembly in aqueous solution to form well-defined, glucose-presenting, particles is reported. The particles formed are susceptible to enzyme-mediated (lipase and protease) and pH-induced degradation, and can selectively bind the lectin concanavalin A. Consequently, such glycoparticles are of significance for the controlled release of payload molecules in response to an acidic environment, for instance cancerous tissue, and upon interaction with target enzymes.

Graphical abstract: Glucose-bearing biodegradable poly(amino acid) and poly(amino acid)-poly(ester) conjugates for controlled payload release

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Publication details

The article was received on 08 Aug 2016, accepted on 15 Oct 2016 and first published on 25 Oct 2016


Article type: Paper
DOI: 10.1039/C6BM00535G
Citation: Biomater. Sci., 2016,4, 1792-1801
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    Glucose-bearing biodegradable poly(amino acid) and poly(amino acid)-poly(ester) conjugates for controlled payload release

    M. Khuphe, C. S. Mahon and P. D. Thornton, Biomater. Sci., 2016, 4, 1792
    DOI: 10.1039/C6BM00535G

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