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Issue 1, 2016
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Utilising inorganic nanocarriers for gene delivery

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Abstract

The delivery of genetic materials into cells to elicit cellular responses has been extensively studied by biomaterials scientists globally. Many materials such as lipids, peptides, viruses, synthetically modified cationic polymers and certain inorganic nanomaterials could be used to complex the negatively charged plasmids and deliver the formed package into cells. The recent literature on the delivery of genetic materials utilising inorganic nanoparticles is carefully examined in this review. We have picked out the most relevant references and concisely summarised the findings with illustrated examples. We further propose alternative approaches and suggest future pathways towards the practical use of multifunctional nanocarriers.

Graphical abstract: Utilising inorganic nanocarriers for gene delivery

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Publication details

The article was received on 25 Jul 2015, accepted on 30 Sep 2015 and first published on 20 Oct 2015


Article type: Review Article
DOI: 10.1039/C5BM00277J
Citation: Biomater. Sci., 2016,4, 70-86
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    Utilising inorganic nanocarriers for gene delivery

    X. J. Loh, T. Lee, Q. Dou and G. R. Deen, Biomater. Sci., 2016, 4, 70
    DOI: 10.1039/C5BM00277J

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