Issue 24, 2016

Graphene quantum dots and Nafion composite as an ultrasensitive electrochemical sensor for the detection of dopamine

Abstract

A novel electrochemical sensor for highly sensitive and selective detection of dopamine (DA) was developed based on a graphene quantum dots (GQDs) and Nafion composite modified glassy carbon electrode (GCE). GQDs were synthesized by a hydrothermal approach for cutting graphene sheets into GQDs and characterized by TEM, UV-vis, photoluminescence, and FT-IR spectra. The GQDs had carboxyl groups with a negative charge, which not only provided good stability, but also enabled interaction with amine functional groups in DA through electrostatic interaction to enhance the specificity of DA. The interaction and electron communication between GQDs and DA can be further strengthened via π–π stacking force. Nafion was used as an anchoring agent to increase the robustness of GQDs on the electrode surface and sensor stability and reproducibility. The GQDs–Nafion composite exhibits a good linear range of 5 nM to 100 μM and a limit of detection as low as 0.45 nM in the detection of DA. The proposed electrochemical sensor also displays good selectivity and high stability and could be used for the determination of DA in real samples with satisfactory results. The present study provides a powerful avenue for the design of an ultrasensitive detection method for clinical application.

Graphical abstract: Graphene quantum dots and Nafion composite as an ultrasensitive electrochemical sensor for the detection of dopamine

Article information

Article type
Paper
Submitted
28 Apr 2016
Accepted
20 May 2016
First published
24 May 2016

Anal. Methods, 2016,8, 4912-4918

Graphene quantum dots and Nafion composite as an ultrasensitive electrochemical sensor for the detection of dopamine

P. Pang, F. Yan, H. Li, H. Li, Y. Zhang, H. Wang, Z. Wu and W. Yang, Anal. Methods, 2016, 8, 4912 DOI: 10.1039/C6AY01254J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements