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Issue 16, 2016
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Simplifying microfluidic separation devices towards field-detection of blood parasites

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Abstract

With our sights set on a simple and inexpensive diagnostics device based on extraction and enrichment of parasites from human blood, we present a device design that relies on a combination of multiple different deterministic lateral displacement arrays. Our end goal is a microfluidic device that will be easy to use in the rural, resource-deprived areas where simple-to-use medical tools are crucially needed for rapid and accurate diagnosis. Here, we exemplify this in the application of blood parasite enrichment from a sample of blood. With trypanosomes as a model system we show a combination of functionalities designed into a single device based on several deterministic lateral displacement arrays of different depths arranged in series. With only one inlet and no expensive or complicated pumping mechanisms to run separations we ensure the level of simplicity necessary for field use.

Graphical abstract: Simplifying microfluidic separation devices towards field-detection of blood parasites

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Publication details

The article was received on 14 Feb 2016, accepted on 20 Feb 2016 and first published on 08 Mar 2016


Article type: Paper
DOI: 10.1039/C6AY00443A
Citation: Anal. Methods, 2016,8, 3291-3300
  • Open access: Creative Commons BY license
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    Simplifying microfluidic separation devices towards field-detection of blood parasites

    S. H. Holm, J. P. Beech, M. P. Barrett and J. O. Tegenfeldt, Anal. Methods, 2016, 8, 3291
    DOI: 10.1039/C6AY00443A

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