Jump to main content
Jump to site search

Issue 19, 2016
Previous Article Next Article

Deciphering the quenching mechanism of 2D MnO2 nanosheets towards Au nanocluster fluorescence to design effective glutathione biosensors

Author affiliations

Abstract

Two-dimensional (2D) nanomaterials (such as 2D MnO2 nanosheets) have received increasing attention due to their unique photophysical properties, rich redox chemistry, excellent colloidal stability, good biocompatibility, etc. Recently, numerous sensing platforms have been reported by exploring the 2D MnO2 nanosheet mediated fluorescence quenching towards fluorophores and/or redox reactions between MnO2 and reductive targets. Though various fluorophores have been used in 2D MnO2 nanosheet based turn-on sensing systems, ultrasmall metal nanoclusters have not been exploited yet. Furthermore, the quenching mechanisms of MnO2 nanosheets towards various fluorophores have remained elusive. To address these issues, we studied the quenching of Au nanocluster fluorescence by 2D MnO2 nanosheets. First, we demonstrated that 2D MnO2 nanosheets were effective quenchers towards the fluorescence of metal nanoclusters (e.g., AuNC@BSA, the bovine serum albumin stabilized Au nanocluster). We further revealed that both dynamic and static quenching effects played critical roles in the quenching process while fluorescence resonance energy transfer (FRET) and inner filter effect (IFE) only played very minor roles in the quenching process. Finally, we developed a turn-on sensing strategy for detection of glutathione (GSH), an important antioxidant with good sensitivity and selectivity. This work provides useful insights in understanding the mechanisms of nanomaterial-induced fluorescence quenching. It also paves a way to design turn-on fluorescent sensors for important reductive targets.

Graphical abstract: Deciphering the quenching mechanism of 2D MnO2 nanosheets towards Au nanocluster fluorescence to design effective glutathione biosensors

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 Jan 2016, accepted on 12 Apr 2016 and first published on 14 Apr 2016


Article type: Paper
DOI: 10.1039/C6AY00199H
Citation: Anal. Methods, 2016,8, 3935-3940
  •   Request permissions

    Deciphering the quenching mechanism of 2D MnO2 nanosheets towards Au nanocluster fluorescence to design effective glutathione biosensors

    S. Lin, H. Cheng, Q. Ouyang and H. Wei, Anal. Methods, 2016, 8, 3935
    DOI: 10.1039/C6AY00199H

Search articles by author

Spotlight

Advertisements