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Issue 12, 2016
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Factors influencing polyelectrolyte-aptamer multilayered films with target-controlled permeability for sensing applications

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Abstract

Portable, easy-to-use and cost-effective sensing devices are desirable in healthcare, environmental monitoring and food safety. Herein we employ polyelectrolyte-aptamer (PE-aptamer) multilayered films that exhibit target-responsive permeability for colorimetric and electrochemical sensing. We present the quantitative detection of an exemplary small molecule, quinine, and address the potential for detection in complex media by examining interference effects. We optimize the film composition and investigate the importance of the structural-switching ability of the aptamer. The results from both platforms are corroborated to provide an outlook on the applicability of the PE-aptamer film for sensing. The label-free detection combined with the readily adaptive assembly process could be invaluable for diverse analytical fields.

Graphical abstract: Factors influencing polyelectrolyte-aptamer multilayered films with target-controlled permeability for sensing applications

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Publication details

The article was received on 23 Oct 2015, accepted on 14 Dec 2015 and first published on 15 Dec 2015


Article type: Paper
DOI: 10.1039/C5AN02198G
Author version available: Download Author version (PDF)
Citation: Analyst, 2016,141, 3794-3802
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    Factors influencing polyelectrolyte-aptamer multilayered films with target-controlled permeability for sensing applications

    B. Malile and J. I. L. Chen, Analyst, 2016, 141, 3794
    DOI: 10.1039/C5AN02198G

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