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Issue 2, 2016
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Emerging techniques in the isolation and characterization of extracellular vesicles and their roles in cancer diagnostics and prognostics

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Abstract

Extracellular vesicles (EVs) are cell-derived nanovesicles, present in almost all types of body fluids, which play an important role in intercellular communication and are involved in the transport of biological signals for regulating diverse cellular functions. Due to the increasing clinical interest in the role of EVs in tumor promotion, various techniques for their isolation, detection, and characterization are being developed. In this review, we present an overview of the current EV isolation and characterization methods in addition to their applications and limitations. Furthermore, EVs as the potential emerging biomarkers in cancer management and their clinical implementation are briefly discussed.

Graphical abstract: Emerging techniques in the isolation and characterization of extracellular vesicles and their roles in cancer diagnostics and prognostics

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Publication details

The article was received on 29 Aug 2015, accepted on 25 Oct 2015 and first published on 26 Oct 2015


Article type: Minireview
DOI: 10.1039/C5AN01775K
Citation: Analyst, 2016,141, 371-381
  • Open access: Creative Commons BY-NC license
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    Emerging techniques in the isolation and characterization of extracellular vesicles and their roles in cancer diagnostics and prognostics

    V. Sunkara, H. Woo and Y. Cho, Analyst, 2016, 141, 371
    DOI: 10.1039/C5AN01775K

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