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Issue 6, 2015
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The cytotoxic mechanisms of disulfiram and copper(II) in cancer cells

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Abstract

The anticancer activity of disulfiram (DS) is copper(II) (Cu)-dependent. This study investigated the anticancer mechanisms of DS/Cu using in vitro cytotoxicity and metabolic kinetic analysis. Our study indicates that DS/Cu targets cancer cells by the combination of two types of actions: (1) instant killing executed by DS/Cu reaction generated reactive oxygen species; (2) delayed cytotoxicity introduced by the end product, DDC-Cu. Nanoencapsulation of DS might shed light on repositioning of DS into cancer treatment.

Graphical abstract: The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells

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Publication details

The article was received on 27 Jun 2015, accepted on 30 Aug 2015 and first published on 01 Sep 2015


Article type: Communication
DOI: 10.1039/C5TX00210A
Citation: Toxicol. Res., 2015,4, 1439-1442
  • Open access: Creative Commons BY license
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    The cytotoxic mechanisms of disulfiram and copper(II) in cancer cells

    P. E. Tawari, Z. Wang, M. Najlah, C. W. Tsang, V. Kannappan, P. Liu, C. McConville, B. He, A. L. Armesilla and W. Wang, Toxicol. Res., 2015, 4, 1439
    DOI: 10.1039/C5TX00210A

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