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Issue 5, 2015
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In vitro toxicological characterisation of arsenic-containing fatty acids and three of their metabolites

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Abstract

Arsenic-containing fatty acids are a group of fat-soluble arsenic species (arsenolipids) which are present in marine fish and other seafood. Recently, it has been shown that arsenic-containing hydrocarbons, another group of arsenolipids, exert toxicity in similar concentrations comparable to arsenite although the toxic modes of action differ. Hence, a risk assessment of arsenolipids is urgently needed. In this study the cellular toxicity of a saturated (AsFA 362) and an unsaturated (AsFA 388) arsenic-containing fatty acid and three of their proposed metabolites (DMAV, DMAPr and thio-DMAPr) were investigated in human liver cells (HepG2). Even though both arsenic-containing fatty acids were less toxic as compared to arsenic-containing hydrocarbons and arsenite, significant effects were observable at μM concentrations. DMAV causes effects in a similar concentration range and it could be seen that it is metabolised to its highly toxic thio analogue thio-DMAV in HepG2 cells. Nevertheless, DMAPr and thio-DMAPr did not exert any cytotoxicity. In summary, our data indicate that risks to human health related to the presence of arsenic-containing fatty acids in marine food cannot be excluded. This stresses the need for a full in vitro and in vivo toxicological characterisation of these arsenolipids.

Graphical abstract: In vitro toxicological characterisation of arsenic-containing fatty acids and three of their metabolites

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Publication details

The article was received on 22 Apr 2015, accepted on 17 Jun 2015, published on 17 Jun 2015 and first published online on 17 Jun 2015


Article type: Paper
DOI: 10.1039/C5TX00122F
Citation: Toxicol. Res., 2015,4, 1289-1296
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    In vitro toxicological characterisation of arsenic-containing fatty acids and three of their metabolites

    S. Meyer, G. Raber, F. Ebert, L. Leffers, S. M. Müller, M. S. Taleshi, K. A. Francesconi and T. Schwerdtle, Toxicol. Res., 2015, 4, 1289
    DOI: 10.1039/C5TX00122F

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