Jump to main content
Jump to site search

Issue 38, 2015
Previous Article Next Article

Inherently fluorescent and porous zirconia colloids: preparation, characterization and drug adsorption studies

Author affiliations

Abstract

Porous, fluorescent zirconia particles of nearly 380 nm diameter were prepared without template molecules or labeling dyes. The porous structure is the result of aggregation-induced particle formation. The inherent fluorescence is assigned to coordinatively unsaturated Zr4+ ions at the sol–gel derived ZrO2 surface. After physico-chemical characterization of the native zirconia particles carboxyl and/or amine bearing drug molecules (D,L-α-difluoromethylornithine – DFMO, ursolic acid – UA and doxorubicin – DOX) were adsorbed onto their surface, and the products were analyzed with Fourier-transform infrared spectroscopy (FTIR), thermogravimetry (TG), small-angle X-ray scattering (SAXS), fluorimetry and zeta potential vs. pH measurements. We have found that DOX complexes coordinatively unsaturated Zr4+ ions without dislocating them, while carboxyl-bearing drugs interact with basic surface Zr–OH sites eliminating some of the carbonate species. The adsorption of UA at the zirconia surface shifts considerably the isoelectric point of the surface and thus provides kinetic stability to the particles at physiological pH. An in vivo biodistribution study in two healthy dogs performed by SPECT/CT detection after 99mTc labeling of the nanocarriers has shown the possibility of drug delivery application.

Graphical abstract: Inherently fluorescent and porous zirconia colloids: preparation, characterization and drug adsorption studies

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 May 2015, accepted on 21 Aug 2015 and first published on 24 Aug 2015


Article type: Paper
DOI: 10.1039/C5TB00832H
Author version available: Download Author version (PDF)
Citation: J. Mater. Chem. B, 2015,3, 7529-7537
  •   Request permissions

    Inherently fluorescent and porous zirconia colloids: preparation, characterization and drug adsorption studies

    L. Naszályi Nagy, J. Mihály, A. Polyak, B. Debreczeni, B. Császár, I. Cs. Szigyártó, A. Wacha, Zs. Czégény, E. Jakab, Sz. Klébert, E. Drotár, G. Dabasi, A. Bóta, L. Balogh and É. Kiss, J. Mater. Chem. B, 2015, 3, 7529
    DOI: 10.1039/C5TB00832H

Search articles by author

Spotlight

Advertisements