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Issue 31, 2015
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Disulfide-gated mesoporous silica nanoparticles designed for two-photon-triggered drug release and imaging

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Abstract

We report a two-photon-actuated cancer cell killing system that kills the cancer cells via drug delivery through multifunctional mesoporous silica nanogates. Two-photon-sensitive mesoporous organosilica (M2PS) nanocarriers were synthesized via the co-condensation of a silica precursor and a two-photon electron donor. The nanogates were constructed using a fast one-pot process at room temperature on the drug-loaded M2PS nanoparticles (NPs) with the bis(3-triethoxysilylpropyl)disulfide precursor. One and two-photon-actuated cargo releases from the M2PS nanogates were successfully monitored in aqueous solutions. Furthermore, the cellular uptake in MCF-7 cells was demonstrated via two-photon fluorescence imaging of the NPs, which were then applied successfully for drug delivery in cells.

Graphical abstract: Disulfide-gated mesoporous silica nanoparticles designed for two-photon-triggered drug release and imaging

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Publication details

The article was received on 30 Apr 2015, accepted on 02 Jul 2015 and first published on 02 Jul 2015


Article type: Paper
DOI: 10.1039/C5TB00797F
Citation: J. Mater. Chem. B, 2015,3, 6456-6461
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    Disulfide-gated mesoporous silica nanoparticles designed for two-photon-triggered drug release and imaging

    J. G. Croissant, C. Qi, O. Mongin, V. Hugues, M. Blanchard-Desce, L. Raehm, X. Cattoën, M. Wong Chi Man, M. Maynadier, M. Gary-Bobo, M. Garcia, J. I. Zink and J. Durand, J. Mater. Chem. B, 2015, 3, 6456
    DOI: 10.1039/C5TB00797F

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