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Issue 26, 2015
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Influence of the synthetic method on the properties of two-photon-sensitive mesoporous silica nanoparticles

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Abstract

Herein we report the modulation of the properties of mesoporous silica nanoparticles (NPs) via various synthetic approaches. Three types of elaborations were compared, one in aqueous media at 25 °C, and the other two at 80 °C in water or in a water–ethanol mixture. For all these methods, an alkoxysilylated two-photon photosensitizer (2PS) was co-condensed with tetraethylorthosilicate (TEOS) in the presence of cetyltrimethylammonium bromide (CTAB), leading to five two-photon-sensitive mesoporous silica (M2PS) NPs. The M2PS NP porous structure could be tuned from radial to worm-like and MCM-41 types of organization. Besides, the 2PS precursor spatial dispersion was found to be highly dependent on both the 2PS initial concentration and the elaboration process. As a result, two-photon properties were modulated by the choice of the synthesis, the best results being found in aqueous media at 25 or 80 °C. Finally, the M2PS NPs were used for in vitro two-photon imaging of cancer cells.

Graphical abstract: Influence of the synthetic method on the properties of two-photon-sensitive mesoporous silica nanoparticles

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Publication details

The article was received on 28 Apr 2015, accepted on 11 May 2015 and first published on 18 May 2015


Article type: Paper
DOI: 10.1039/C5TB00787A
Citation: J. Mater. Chem. B, 2015,3, 5182-5188
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    Influence of the synthetic method on the properties of two-photon-sensitive mesoporous silica nanoparticles

    J. G. Croissant, O. Mongin, V. Hugues, M. Blanchard-Desce, X. Cattoën, M. Wong Chi Man, V. Stojanovic, C. Charnay, M. Maynadier, M. Gary-Bobo, M. Garcia, L. Raehm and J. Durand, J. Mater. Chem. B, 2015, 3, 5182
    DOI: 10.1039/C5TB00787A

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