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Issue 19, 2015
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Calcium phosphate nanocapsule crowned multiwalled carbon nanotubes for pH triggered intracellular anticancer drug release

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Abstract

We report calcium phosphate (CaP) nanocapsule crowned multiwalled carbon nanotubes (CNT–GSH–G4–CaP) as a novel platform for intracellular delivery of an anticancer drug. As a proof-of-concept, CNT–GSH–G4–CaP demonstrates release of anticancer drug doxorubicin hydrochloride (DOX) within intracellular lysosomes from the interior cavity of CNT upon pH triggered CaP dissolution. Importantly, we found that the CNT with a CaP nanolid can efficiently prevent untimely drug release at physiological pH but promotes DOX release at increased acidic milieu as observed in subcellular compartments such as lysosomes (∼5.0). This “zero premature release” characteristic is of clinical significance in delivering cytotoxic drugs, by reducing systemic toxicity and thus beneficial for the effective anticancer treatment. We envision that this pH triggered CaP crowned CNT nanosystem would lead to a new generation of self-regulated platforms for intracellular delivery of a variety of anticancer drugs.

Graphical abstract: Calcium phosphate nanocapsule crowned multiwalled carbon nanotubes for pH triggered intracellular anticancer drug release

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Publication details

The article was received on 24 Mar 2015, accepted on 17 Apr 2015 and first published on 17 Apr 2015


Article type: Communication
DOI: 10.1039/C5TB00534E
Author version available: Download Author version (PDF)
Citation: J. Mater. Chem. B, 2015,3, 3931-3939
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    Calcium phosphate nanocapsule crowned multiwalled carbon nanotubes for pH triggered intracellular anticancer drug release

    S. S. Banerjee, K. J. Todkar, G. V. Khutale, G. P. Chate, A. V. Biradar, M. B. Gawande, R. Zboril and J. J. Khandare, J. Mater. Chem. B, 2015, 3, 3931
    DOI: 10.1039/C5TB00534E

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