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Issue 22, 2015
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Tailoring pH-responsive acrylic acid microgels with hydrophobic crosslinks for drug release

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Abstract

Amphiphilic microgels based on the hydrophilic acrylic acid (AA) and hydrophobic crosslinks of different compositions were synthesised using a lab-on-a-chip device. The microgels were formed by polymerising hydrophobic droplets. The droplets were generated via a microfluidic platform and contained a protected form of AA, a hydrophobic crosslinker (ethylene glycol dimethacrylate, EGDMA) and a free radical initiator in an organic solvent. Following photopolymerisation and subsequent hydrolysis, AA based microgels of amphiphilic nature were produced and it was demonstrated that they can successfully deliver both hydrophilic as well as hydrophobic moieties. The model drug delivery and the swelling ability of the microgels were influenced by the pH of the aqueous solution as well as the crosslinking density and hydrophobic content of the microgels.

Graphical abstract: Tailoring pH-responsive acrylic acid microgels with hydrophobic crosslinks for drug release

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Publication details

The article was received on 30 Jan 2015, accepted on 05 May 2015 and first published on 05 May 2015


Article type: Paper
DOI: 10.1039/C5TB00222B
Author version available: Download Author version (PDF)
Citation: J. Mater. Chem. B, 2015,3, 4524-4529
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    Tailoring pH-responsive acrylic acid microgels with hydrophobic crosslinks for drug release

    B. Lu, M. D. Tarn, N. Pamme and T. K. Georgiou, J. Mater. Chem. B, 2015, 3, 4524
    DOI: 10.1039/C5TB00222B

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