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Issue 25, 2015
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Photoelectric artefact from optogenetics and imaging on microelectrodes and bioelectronics: new challenges and opportunities

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Abstract

Bioelectronics, electronic technologies that interface with biological systems, are experiencing rapid growth in terms of technology development and applications, especially in neuroscience and neuroprosthetic research. The parallel growth with optogenetics and in vivo multi-photon microscopy has also begun to generate great enthusiasm for simultaneous applications with bioelectronic technologies. However, emerging research showing artefact contaminated data highlight the need for understanding the fundamental physical principles that critically impact experimental results and complicate their interpretation. This review covers four major topics: (1) material dependent properties of the photoelectric effect (conductor, semiconductor, organic, photoelectric work function (band gap)); (2) optic dependent properties of the photoelectric effect (single photon, multiphoton, entangled biphoton, intensity, wavelength, coherence); (3) strategies and limitations for avoiding/minimizing photoelectric effects; and (4) advantages of and applications for light-based bioelectronics (photo-bioelectronics).

Graphical abstract: Photoelectric artefact from optogenetics and imaging on microelectrodes and bioelectronics: new challenges and opportunities

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Publication details

The article was received on 16 Jan 2015, accepted on 07 Apr 2015 and first published on 13 Apr 2015


Article type: Review Article
DOI: 10.1039/C5TB00108K
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Citation: J. Mater. Chem. B, 2015,3, 4965-4978
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    Photoelectric artefact from optogenetics and imaging on microelectrodes and bioelectronics: new challenges and opportunities

    T. D. Y. Kozai and A. L. Vazquez, J. Mater. Chem. B, 2015, 3, 4965
    DOI: 10.1039/C5TB00108K

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