Issue 6, 2015

Polyelectrolyte-mediated hierarchical mesoporous calcium silicates: a platform for drug delivery carrier with ultrahigh loading capacity and controlled release behavior

Abstract

We have developed a facile method for the poly(allylamine hydrochloride) (PAH)-assisted synthesis of mesoporous calcium silicate hydrates (PAH-CS) with a large specific surface area (BET = 348.4 m2 g−1) and pore volume (Vp = 1.42 cm3 g−1). Tetraethyl orthosilicate (TEOS) was employed as a silicon source, which was rapidly hydrolyzed and reacted with the amine groups of PAH to form spherical SiO2 nanoparticles (PAH-Si). Subsequently, Ca2+ ions reacted with the silicate anions produced during the dissolution of SiO2 in basic media, leading to the formation of the highly porous 3D networks of PAH-CS that were synthesized only under optimized reaction conditions. The PAH-CS containing an excess of Ca2+ and NH3+ enriched the surfaces with a very high cationic charge (ζ = +65.66 mV)and resulted in an extremely high loading capacity for anionic drugs and proteins. Ibuprofen (IBU) and FITC-labeled bovine albumin (FITC-Albumin) were chosen as a model drug and model protein, respectively, to test the loading and delivery efficiencies of the PAH-CS carriers. The ultrahigh drug loading capacities (DLC) and their release patterns were investigated under controlled pH conditions. Strikingly, the highest DLC reported to date (IBU or FITC-Albumin/carrier (3.35 g or 1 g g−1) was achieved in this work. The PAH-CS had no cytotoxic effect on osteoblast-like MC3T3-E1 cell lines evaluated by the LDH (Lactate dehydrogenase) assay in supernatant medium. Furthermore, the PAH-CS carriers could be entirely transformed to hydroxyapatite after releasing the drug in simulated body fluid (SBF), indicating good bioactivity and biodegradability of the PAH-CS carriers.

Graphical abstract: Polyelectrolyte-mediated hierarchical mesoporous calcium silicates: a platform for drug delivery carrier with ultrahigh loading capacity and controlled release behavior

Supplementary files

Article information

Article type
Paper
Submitted
19 Nov 2014
Accepted
18 Dec 2014
First published
18 Dec 2014

J. Mater. Chem. B, 2015,3, 1001-1009

Polyelectrolyte-mediated hierarchical mesoporous calcium silicates: a platform for drug delivery carrier with ultrahigh loading capacity and controlled release behavior

Md. S. Islam, H. N. Choi, W. S. Choi and H. Lee, J. Mater. Chem. B, 2015, 3, 1001 DOI: 10.1039/C4TB01911C

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