Jump to main content
Jump to site search

Issue 47, 2015
Previous Article Next Article

A vegetable oil-based organogel for use in pH-mediated drug delivery

Author affiliations

Abstract

Organogels prepared with vegetable oils as the liquid organic phase present an excellent platform for the controlled delivery of hydrophobic guest molecules. We disclose a graft copolymer comprised of a poly(L-serine) backbone linked to alkane side-chains by hydrolytically susceptible ester bonds, that is capable of gelating edible safflower oil. The thermoresponsive organogel formed, which is non-cytotoxic, is capable of withholding guest molecules before undergoing targeted disassembly upon incubation in solutions of acidic pH, permitting the directed release of payload molecules. The presented material offers an extremely promising candidate for the controlled delivery of hydrophobic agents within acidic environments, such as cancer tumour sites.

Graphical abstract: A vegetable oil-based organogel for use in pH-mediated drug delivery

Back to tab navigation

Supplementary files

Publication details

The article was received on 28 Aug 2015, accepted on 18 Sep 2015 and first published on 18 Sep 2015


Article type: Paper
DOI: 10.1039/C5SM02176F
Author version available: Download Author version (PDF)
Citation: Soft Matter, 2015,11, 9160-9167
  •   Request permissions

    A vegetable oil-based organogel for use in pH-mediated drug delivery

    M. Khuphe, B. Mukonoweshuro, A. Kazlauciunas and P. D. Thornton, Soft Matter, 2015, 11, 9160
    DOI: 10.1039/C5SM02176F

Search articles by author

Spotlight

Advertisements