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Issue 37, 2015
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Revealing the trehalose mediated inhibition of protein aggregation through lysozyme–silver nanoparticle interaction

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Abstract

We propose a facile and robust carbohydrate-mediated method for the prevention of nanoparticle induced denaturation and aggregation of proteins. Using label-free plasmon-enhanced Raman spectroscopy measurements, the mechanistic principles of trehalose stabilization in a model protein–nanoparticle system are elucidated for the first time, facilitating its further application in diagnostic and therapeutic nanoplex development.

Graphical abstract: Revealing the trehalose mediated inhibition of protein aggregation through lysozyme–silver nanoparticle interaction

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Publication details

The article was received on 30 Jul 2015, accepted on 04 Aug 2015 and first published on 04 Aug 2015


Article type: Communication
DOI: 10.1039/C5SM01896J
Author version available: Download Author version (PDF)
Citation: Soft Matter, 2015,11, 7241-7249
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    Revealing the trehalose mediated inhibition of protein aggregation through lysozyme–silver nanoparticle interaction

    S. Siddhanta, I. Barman and C. Narayana, Soft Matter, 2015, 11, 7241
    DOI: 10.1039/C5SM01896J

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